甲氨蝶呤 [ 59-05-2 ]

规格：

USP29
Appearance  Yellow crystalline powder
Identification        IR, UV conform
Water    Not more than 12.0%
Residue on ignition     Not more than 0.1%
Chromatographic purity
Total impurities: not more than 2.0%
Individual impurity: not more than 0.5%
Specific rotation Between +19°~+24°
Organic volatile impurities  Conforms
Bacterial endotoxins   Not more than 0.4EU/mg
Assay     98.0~102.0%

UN 2811 6.1/PG 3

该品是较好的抗肿瘤药物，用于急性淋巴白血病、淋巴瘤、恶性葡萄胎、绒癌、鳞状上皮癌、肺癌、宫颈癌、乳腺癌和成骨肉瘤等。甲氨喋呤口服12h后原药90%从尿中排出，主要代谢物为7-羟基甲氨蝶呤。大鼠静脉注射LD50为14mg/kg。